Purification and structural studies on the complement-system control protein β1H (Factor H)
نویسندگان
چکیده
منابع مشابه
cloning, expression and purification of the factor h binding protein and its interaction with factor h
background and objective: neisseria meningitidis is a leading cause of meningitis and sepsis worldwide. the factor h binding protein (fhbp) is a key virulence factor of neisseria meningitidis that is able to selectively bind to human factor h, the key regulator of the alternative complement pathway, which it has important implications for meningococcal pathogene- sis and vaccine design. the aim...
متن کاملTranslational mini-review series on complement factor H: structural and functional correlations for factor H.
The 155-kDa glycoprotein, complement factor H (CFH), is a regulator of complement activation that is abundant in human plasma. Three-dimensional structures of over half the 20 complement control protein (CCP) modules in CFH have been solved in the context of single-, double- and triple-module segments. Proven binding sites for C3b occupy the N and C termini of this elongated molecule and may be...
متن کاملCloning, expression and purification of the factor H binding protein and its interaction with factor H
BACKGROUND AND OBJECTIVE Neisseria meningitidis is a leading cause of meningitis and sepsis worldwide. The factor H binding protein (fHBP) is a key virulence factor of Neisseria meningitidis that is able to selectively bind to human factor H, the key regulator of the alternative complement pathway, which it has important implications for meningococcal pathogenesis and vaccine design. The aims o...
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C4b-binding protein (C4BP) is a potent inhibitor of the classical pathway of the complement system. This large plasma glycoprotein consists of seven identical alpha-chains and a unique beta-chain held together by disulphide bridges. Both types of subunits are composed almost exclusively of complement control protein domains (CCPs). Using homology-based computer modelling and mutagenesis of reco...
متن کاملComplement factor H regulation in the central nervous system
Approved: ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date COMPLEMENT FACTOR H REGULATION IN THE CENTRAL NERVOUS SYSTEM by Laura Anne Fraczek A thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in Immunology in the Graduate College of The Univer...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1982
ISSN: 0264-6021
DOI: 10.1042/bj2050285